Lautt W W
Can J Physiol Pharmacol. 1979 Sep;57(9):1037-9. doi: 10.1139/y79-156.
Using a newly described method for obtaining pure, mixed hepatic venous blood samples, it was demonstrated that glucose mobilization from the liver of the anesthetized cat in response to hepatic nerve stimulation is via alpha-adrenergic receptors. Neither the elevation of portal pressure nor the amount of glucose generated by the liver was affected by intraportal administration of 1 mg propranolol/kg (beta blockade). In the presence of alpha-receptor blockade (3 mg phentolamine/kg) the portal venous pressure change was minor and the glucose output actually decreased slightly upon nerve stimulation, a response consistent with our previously demonstrated reduction of glucose output by parasympathetic nerve stimulation. The present responses to nerve stimulation were not due to activation of pancreatic nerves since these nerves were routinely ligated.
运用一种新描述的获取纯净混合肝静脉血样本的方法，结果表明，麻醉猫肝脏在受到肝神经刺激时，葡萄糖动员是通过α-肾上腺素能受体进行的。门静脉压力升高以及肝脏产生的葡萄糖量均不受门静脉内注射1毫克普萘洛尔/千克（β受体阻滞）的影响。在存在α受体阻滞（3毫克酚妥拉明/千克）的情况下，门静脉压力变化较小，且神经刺激时葡萄糖输出实际上略有下降，这一反应与我们之前证明的副交感神经刺激使葡萄糖输出减少相一致。目前对神经刺激的反应并非由于胰腺神经的激活，因为这些神经已常规结扎。
