Lautt W W, Wong C
Can J Physiol Pharmacol. 1978 Dec;56(6):1022-8. doi: 10.1139/y78-163.
Changes in hepatic glucose balance in response to direct stimulation of the hepatic nerves were measured in cats. Simultaneous measurements were made of glucose concentrations entering and leaving the intact liver; this, combined with measured blood flows, allows calculation of hepatic glucose balance. Stimulation of the hepatic sympathetic nerves (8 Hz, 15 V, 1 ms) produced a rapid increase in hepatic glucose output that was statistically significant after 1 min and reached a peak 3--5 min after onset of stimulation, after which time the output declined somewhat. The half time for deactivation of the response was 1.8--2 min. Variability in the responses was largely accounted for by the variable control base lines measured immediately prior to stimulation. Those animals showing the highest basal output showed the least increase in output in response to the nerves. The response to stimulation of the mixed nerve trunk in the presence and absence of atropine (1 mg/kg, intraportal) was similar. Simultaneous activation of hepatic sympathetic and parasympathetic nerves therefore produces a purely sympathetic type of effect on net glucose balance across the liver. It was also shown that changes in net splanchnic output or simply in arterial--hepatic venous glucose differences are an adequate reflection of liver glucose balance under the currently tested responses.
在猫身上测量了肝脏神经直接刺激后肝脏葡萄糖平衡的变化。同时测量了进入和离开完整肝脏的葡萄糖浓度；这与测量的血流相结合，可计算肝脏葡萄糖平衡。刺激肝脏交感神经（8赫兹，15伏，1毫秒）会使肝脏葡萄糖输出迅速增加，1分钟后具有统计学意义，并在刺激开始后3至5分钟达到峰值，此后输出有所下降。反应失活的半衰期为1.8至2分钟。反应的变异性在很大程度上是由刺激前立即测量的可变对照基线造成的。那些基础输出最高的动物对神经刺激的输出增加最少。在有和没有阿托品（1毫克/千克，门静脉内注射）的情况下，对混合神经干刺激的反应相似。因此，同时激活肝脏交感神经和副交感神经会对整个肝脏的净葡萄糖平衡产生纯粹的交感神经类型的影响。还表明，在内脏净输出的变化或仅仅是动脉-肝静脉葡萄糖差异的变化是当前测试反应下肝脏葡萄糖平衡的充分反映。
