Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.
Int J Biochem Cell Biol. 2012 Dec;44(12):2175-84. doi: 10.1016/j.biocel.2012.09.007. Epub 2012 Sep 17.
Haematopoiesis is one of the most intensively studied and best described systems in the body. However, knowledge of cell signalling pathways that drive haematopoietic stem cell (HSC) development and how they interact with each other and with transcription factors that specify HSCs is still rudimentary. In this review, we will highlight recent advances in the field relating to these questions and identify gaps that need to be filled. To this end, we will briefly describe the developmental ontogeny of HSCs and examine in detail the cell signalling pathways that have been implicated in HSC specification. In conclusion we will discuss how this knowledge has led to the generation of blood cells in the laboratory and consider the implications of that advancement.
造血是体内研究最深入、描述最完善的系统之一。然而，对于驱动造血干细胞（HSC）发育的细胞信号通路，以及它们如何相互作用以及与指定 HSC 的转录因子相互作用的知识仍然很基础。在这篇综述中，我们将重点介绍与这些问题相关的领域的最新进展，并确定需要填补的空白。为此，我们将简要描述 HSC 的发育发生，并详细研究与 HSC 特化相关的细胞信号通路。最后，我们将讨论这些知识如何导致实验室中血细胞的生成，并考虑这一进展的意义。
