Kushwah Rahul, Guezguez Borhane, Lee Jung Bok, Hopkins Claudia I, Bhatia Mickie
McMaster Stem Cell and Cancer Research Institute (SCC-RI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
McMaster Stem Cell and Cancer Research Institute (SCC-RI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
EMBO Rep. 2014 Nov;15(11):1128-38. doi: 10.15252/embr.201438842. Epub 2014 Sep 24.
The Notch signaling pathway is evolutionarily conserved across species and plays an important role in regulating cell differentiation, proliferation, and survival. It has been implicated in several different hematopoietic processes including early hematopoietic development as well as adult hematological malignancies in humans. This review focuses on recent developments in understanding the role of Notch signaling in the human hematopoietic system with an emphasis on hematopoietic initiation from human pluripotent stem cells and regulation within the bone marrow. Based on recent insights, we summarize potential strategies for treatment of human hematological malignancies toward the concept of targeting Notch signaling for fate regulation.
Notch信号通路在物种进化过程中高度保守，在调节细胞分化、增殖和存活方面发挥着重要作用。它涉及多种不同的造血过程，包括人类早期造血发育以及成人血液系统恶性肿瘤。本综述重点关注Notch信号在人类造血系统中作用的最新进展，尤其着重于人类多能干细胞的造血起始以及骨髓内的调控。基于近期的研究见解，我们针对命运调控靶向Notch信号的概念，总结了治疗人类血液系统恶性肿瘤的潜在策略。
