Clinic for Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Radiology. 2012 Dec;265(3):933-8. doi: 10.1148/radiol.12120424. Epub 2012 Sep 20.
To evaluate the feasibility of different approaches of instrument visualization for cardiovascular interventions guided by using magnetic particle imaging (MPI).
Two balloon (percutaneous transluminal angioplasty) catheters were used. The balloon was filled either with diluted superparamagnetic iron oxide (SPIO) ferucarbotran (25 mmol of iron per liter) or with sodium chloride. Both catheters were inserted into a vessel phantom that was filled oppositional to the balloon content with sodium chloride or diluted SPIO (25 mmol of iron per liter). In addition, the administration of a 1.4-mL bolus of pure SPIO (500 mmol of iron per liter) followed by 5 mL of sodium chloride through a SPIO-labeled balloon catheter into the sodium chloride-filled vessel phantom was recorded. Images were recorded by using a preclinical MPI demonstrator. All images were acquired by using a field of view of 3.6 × 3.6 × 2.0 cm.
By using MPI, both balloon catheters could be visualized with high temporal (21.54 msec per image) and sufficient spatial (≤ 3 mm) resolution without any motion artifacts. The movement through the field of view, the inflation and deflation of the balloon, and the application of the SPIO bolus were visualized at a rate of 46 three-dimensional data sets per second.
Visualization of SPIO-labeled instruments for cardiovascular intervention at high temporal resolution as well as monitoring the application of a SPIO-based tracer by using labeled instruments is feasible. Further work is necessary to evaluate different labeling approaches for diagnostic catheters and guidewires and to demonstrate their navigation in the vascular system after administration of contrast material.
http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120424/-/DC1.
评估基于磁粒子成像（MPI）的心血管介入中不同器械可视化方法的可行性。
使用了两种球囊（经皮腔内血管成形术）导管。球囊内填充的是稀释的超顺磁性氧化铁（SPIO）ferucarbotran（每升 25mmol 铁）或氯化钠。将这两种导管插入充满与球囊内容物相反的氯化钠或稀释 SPIO（每升 25mmol 铁）的血管模型中。此外，还通过标记有 SPIO 的球囊导管将 1.4mL 纯 SPIO（每升 500mmol 铁）的 bolus 推注到充满氯化钠的血管模型中，随后推注 5mL 氯化钠，同时记录图像。使用临床前 MPI 演示器进行图像记录。所有图像均采用 3.6×3.6×2.0cm 的视野采集。
通过 MPI，可以在高时间分辨率（每张图像 21.54 毫秒）和足够的空间分辨率（≤3mm）下可视化两个球囊导管，而没有任何运动伪影。球囊导管在视野内的移动、球囊的充气和放气以及 SPIO 推注的应用，都可以以每秒 46 个三维数据集的速度进行可视化。
对心血管介入的 SPIO 标记器械进行高时间分辨率的可视化以及通过标记器械监测 SPIO 示踪剂的应用是可行的。还需要进一步工作来评估诊断导管和导丝的不同标记方法，并在注入对比剂后展示其在血管系统中的导航。
http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120424/-/DC1.
