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两个酵母线粒体细胞色素基因内的多效性突变会阻碍mRNA加工。

Pleiotropic mutations within two yeast mitochondrial cytochrome genes block mRNA processing.

作者信息

Church G M, Slonimski P P, Gilbert W

出版信息

Cell. 1979 Dec;18(4):1209-15. doi: 10.1016/0092-8674(79)90233-2.

DOI:10.1016/0092-8674(79)90233-2
PMID:229970
Abstract

The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants seem to lack a functional trans-acting RNA required for the processing of both messengers. In contrast, the oxi-3 mutants may act by producing an activity that inhibits specific steps.

摘要

来自酵母两个线粒体基因 cob-box（细胞色素 b）和 oxi-3（细胞色素氧化酶 40,000 道尔顿亚基）的信使核糖核酸（mRNA）是从大的（7 - 10 千碱基对）前体加工而来的。每个基因中的某些突变在多个特定步骤阻断了这两个基因的 RNA 成熟过程。多效性细胞色素 b 突变体似乎缺乏加工这两种信使 RNA 所需的功能性反式作用 RNA。相比之下，oxi-3 突变体可能通过产生一种抑制特定步骤的活性来发挥作用。

相似文献

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Pleiotropic mutations within two yeast mitochondrial cytochrome genes block mRNA processing.两个酵母线粒体细胞色素基因内的多效性突变会阻碍mRNA加工。
Cell. 1979 Dec;18(4):1209-15. doi: 10.1016/0092-8674(79)90233-2.
2
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引用本文的文献

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Curr Genet. 1981 Apr;3(1):57-63. doi: 10.1007/BF00419581.
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巴龙霉素和[psi]对酿酒酵母线粒体突变抑制的影响。
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5
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