Microgen Laboratories, La Marque, Texas 77568, USA.
J Med Virol. 2012 Nov;84(11):1797-802. doi: 10.1002/jmv.23397.
Recent studies have shown that cytomegalovirus (CMV) may be an emerging marker of immunosenescence. CMV can affect the immune system by directly infecting leukocytes and hematopoietic cells or by eliciting an expansion of oligoclonal CD8+ T cells/contraction of the naïve T cell compartment that may reduce the host's ability to fight other pathogens. To investigate further CMV-associated changes in immunity, a study was conducted with 1,454 adults (ages 25-91) to determine the association between CMV and reactivation of another latent herpesvirus, Herpes simplex virus type 1 (HSV-1), as indexed by antibody titers. Elevated antibody titers to latent HSV-1 were significantly associated with both CMV seropositivity and high CMV antibody levels. Evaluation by specific age groups (<45, 45-64, and 65+ years old) revealed that this association was detectable early in life (<45 years of age). Increases in HSV-1 antibodies by age occurred in CMV seropositive individuals but not CMV seronegative subjects. Within CMV seropositive subjects, increases in HSV-1 antibodies by age were only found in individuals with low CMV antibody levels as those with high CMV antibodies already exhibited elevated HSV-1 antibodies. These associations remained significant after accounting for body mass index, gender, and socioeconomic status. These results suggest that CMV can influence the immune response to another pathogen and support the concept that CMV may accelerate immunosenescence.
最近的研究表明，巨细胞病毒（CMV）可能是免疫衰老的一个新标志物。CMV 可以通过直接感染白细胞和造血细胞，或通过引发寡克隆 CD8+T 细胞的扩增和幼稚 T 细胞库的收缩，从而影响免疫系统，这可能会降低宿主抵抗其他病原体的能力。为了进一步研究 CMV 相关的免疫变化，对 1454 名成年人（年龄 25-91 岁）进行了一项研究，以确定 CMV 与另一种潜伏性疱疹病毒单纯疱疹病毒 1（HSV-1）的再激活之间的关系，其指标为抗体滴度。潜伏性 HSV-1 抗体滴度升高与 CMV 血清阳性和高 CMV 抗体水平均显著相关。通过特定年龄组（<45 岁、45-64 岁和 65 岁以上）进行评估发现，这种关联在生命早期（<45 岁）即可检测到。CMV 血清阳性个体的 HSV-1 抗体随年龄增长而增加，但 CMV 血清阴性个体则不然。在 CMV 血清阳性个体中，只有低 CMV 抗体水平的个体才会出现 HSV-1 抗体随年龄增长的情况，因为高 CMV 抗体水平的个体已经表现出升高的 HSV-1 抗体。在考虑体重指数、性别和社会经济地位后，这些关联仍然显著。这些结果表明，CMV 可以影响对另一种病原体的免疫反应，并支持 CMV 可能加速免疫衰老的概念。
