Rosenthal S L, Stanberry L R, Biro F M, Slaoui M, Francotte M, Koutsoukos M, Hayes M, Bernstein D I
Department of Pediatrics, University of Cincinnati College of Medicine and Children's Hospital Medical Center, Ohio 45229, USA.
Clin Infect Dis. 1997 Feb;24(2):135-9. doi: 10.1093/clinids/24.2.135.
We determined the prevalence of herpes simplex virus (HSV) and cytomegalovirus (CMV) antibodies in a cohort of adolescents 12 to 22 years of age in anticipation of the development of vaccines to control HSV and CMV infections. For the overall study population, we found that 62% were seropositive for HSV type 1 (HSV-1), 12% were seropositive for HSV type 2 (HSV-2), and 65% were seropositive for CMV. Race was not related to HSV-1 seropositivity, but African-American adolescents were more likely than Caucasian adolescents to be seropositive for HSV-2 and CMV. Girls also were more likely than boys to be seropositive for HSV-2 and CMV. For boys, history of a sexually transmitted disease was identified as a risk factor for HSV-2 seropositivity; for girls, a greater number of sexual partners increased the risk of being seropositive for HSV-2. Our data demonstrating a high prevalence of infection during adolescence suggest that immunization for HSV-1, HSV-2, and CMV may need to occur in childhood.
为了研发控制单纯疱疹病毒（HSV）和巨细胞病毒（CMV）感染的疫苗，我们对一组12至22岁的青少年进行了HSV和CMV抗体患病率的测定。对于整个研究人群，我们发现1型单纯疱疹病毒（HSV-1）血清学阳性率为62%，2型单纯疱疹病毒（HSV-2）血清学阳性率为12%，CMV血清学阳性率为65%。种族与HSV-1血清学阳性无关，但非裔美国青少年比白人青少年更易出现HSV-2和CMV血清学阳性。女孩比男孩更易出现HSV-2和CMV血清学阳性。对于男孩，性传播疾病史被确定为HSV-2血清学阳性的危险因素；对于女孩，性伴侣数量增加会增加HSV-2血清学阳性的风险。我们的数据表明青少年感染率很高，这提示HSV-1、HSV-2和CMV的免疫接种可能需要在儿童期进行。
