一种构建苯并氮杂卓和苯并氧杂卓衍生物的有效方法。

An efficient approach for the construction of benzazepine and benzoxepine derivatives.

机构信息

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.

出版信息

Chem Asian J. 2012 Dec;7(12):2882-7. doi: 10.1002/asia.201200636. Epub 2012 Sep 20.

DOI:10.1002/asia.201200636

Abstract

A novel and facile synthetic protocol for the construction of benzazepine and benzoxepine derivatives through a copper(I)-catalyzed reaction of 2-(2-ethynylphenyl)-1-tosylaziridine or 2-(2-ethynylphenyl)oxirane with sulfonyl azides is disclosed. A ketenimine is the key intermediate during the reaction process.

摘要

本文报道了一种通过铜（I）催化 2-(2-乙炔基苯基）-1-对甲苯磺酰基氮丙啶或 2-(2-乙炔基苯基）环氧乙烷与磺酰叠氮的反应构建苯并氮杂卓和苯并氧杂卓衍生物的新颖、简便的合成方法。反应过程中，亚胺叶立德是关键中间体。