Konstanty-Kalandyk Janusz, Piatek Jacek, Rudzinski Pawel, Wrobel Krzysztof, Bartus Krzysztof, Sadowski Jerzy
Department of Cardiovascular Surgery and Transplantology, Collegium Medicum Jagiellonian University, John Paul II Hospital, Krakow, Poland.
Interact Cardiovasc Thorac Surg. 2012 Dec;15(6):979-83. doi: 10.1093/icvts/ivs364. Epub 2012 Sep 20.
The use of bilateral internal thoracic arteries (BITAs) grafting has been documented to be advantageous over left internal thoracic artery (LITA) grafting. It has been shown to significantly improve clinical outcomes and increase long-term survival in patients with diabetes. However, harvesting BITAs may result in a greater risk of superficial wound infection (SWI) or deep sternal wound infection (DSWI) and cardiovascular complications (major adverse cardiac and cerebrovascular events; MACCE) in such a patient group. The objective of this study was to compare the incidence of SWI or DSWI and cardiovascular events in a series of isolated coronary artery bypass grafting (CABG) patients who underwent BITA grafting vs LITA grafting.
A total of 147 patients with coronary artery disease and diabetes underwent isolated CABG at John Paul II Hospital. Of these, 38 procedures were performed using BITA grafting and 109 with LITA-saphenous vein grafting.
MACCE were similar in bilateral groups (7.9%--BITA group and 9.2%--LITA group). No significant difference was found in mortality and length of stay between bilateral groups. The MACCE risk factor was age. The incidence of SWI and DSWI and sternal re-fixation did not differ between the BITA or LITA groups (5.2 vs 9.1%, 5.2 vs 7.3% and 5.2 vs 6.4%). The risk factors for DSWI were age (odds ratio 3.47, P = 0.032 for every 10 years) and body mass index >30 kg/m(2).
Perioperative complications do not increase with the use of BITAs in this group of diabetic patients. There are no statistically significant differences in the number of superficial or deep wound infections or number of sternal resuturing between the BITA and LITA groups.
有文献记载,双侧胸廓内动脉(BITA)移植比左胸廓内动脉(LITA)移植更具优势。研究表明,它能显著改善临床结局并提高糖尿病患者的长期生存率。然而,对于这类患者群体,获取BITA可能会导致更高的浅表伤口感染(SWI)或深部胸骨伤口感染(DSWI)风险以及心血管并发症(主要不良心脑血管事件;MACCE)。本研究的目的是比较一系列接受BITA移植与LITA移植的单纯冠状动脉旁路移植术(CABG)患者中SWI或DSWI以及心血管事件的发生率。
共有147例冠心病合并糖尿病患者在约翰·保罗二世医院接受了单纯CABG。其中,38例采用BITA移植,109例采用LITA - 大隐静脉移植。
双侧组的MACCE相似(BITA组为7.9%,LITA组为9.2%)。双侧组在死亡率和住院时间方面未发现显著差异。MACCE的风险因素是年龄。BITA组和LITA组之间的SWI、DSWI发生率以及胸骨重新固定情况无差异(分别为5.2%对9.1%、5.2%对7.3%和5.2%对6.4%)。DSWI的风险因素是年龄(每10年的比值比为3.47,P = 0.032)和体重指数>30 kg/m²。
在这组糖尿病患者中,使用BITA并不会增加围手术期并发症。BITA组和LITA组在浅表或深部伤口感染数量或胸骨重新缝合数量方面无统计学显著差异。