Department of Microbiology and Infection, Kochi University, Kochi, Japan.
J Virol. 2012 Oct;86(20):11400-1. doi: 10.1128/JVI.01767-12.
Helicobacter pylori causes peptic ulcers and gastric cancer, which lead to significantly higher morbidity in Japan than elsewhere in the world. As bacteriophage (phage) and host bacteria coevolve, the study of H. pylori phages is important to extend understanding of the evolution and pathogenesis of H. pylori. Here we report two complete genome sequences of H. pylori phages KHP30 and KHP40, which were released spontaneously from the most pathogenic East Asian-type isolates from Japanese patients.
幽门螺杆菌会导致消化性溃疡和胃癌,使其在日本的发病率明显高于世界其他地区。由于噬菌体(phage)和宿主细菌共同进化,因此研究幽门螺杆菌噬菌体对于扩展对幽门螺杆菌的进化和发病机制的理解非常重要。在这里,我们报告了两种完整的幽门螺杆菌噬菌体 KHP30 和 KHP40 的基因组序列,它们是从日本患者的最具致病性的东亚型分离株中自发释放的。