Micioni Di Bonaventura Maria Vittoria, Vitale Giovanni, Massi Maurizio, Cifani Carlo
School of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, Italy.
J Obes. 2012;2012:956137. doi: 10.1155/2012/956137. Epub 2012 Sep 10.
Purpose. The present study evaluated the effect of Hypericum perforatum dry extract in an experimental model of binge eating (BE). Methods. BE for highly palatable food (HPF) was evoked in female rats by three 8-day cycles of food restriction/re-feeding and acute stress on the test day (day 25). Stress was induced by preventing access to HPF for 15 min, while rats were able to see and smell it. Hypericum perforatum dry extract was given by gavage. Results. Only rats exposed to both food restrictions and stress exhibited BE. The doses of 250 and 500 mg/kg of Hypericum perforatum extract significantly reduced the BE episode, while 125 mg/kg was ineffective. The same doses did not affect HPF intake in the absence of BE. The dose of 250 mg/kg did not significantly modify stress-induced increase in serum corticosterone levels, suggesting that the effect on BE is not due to suppression of the stress response The combined administration of 125 mg/kg of Hypericum perforatum together with Salidroside, active principle of Rhodiola rosea, produced a synergic effect on BE. Conclusions. The present results indicate for the first time that Hypericum perforatum extracts may have therapeutic properties in bingeing-related eating disorders.
目的。本研究评估了贯叶连翘干提取物在暴饮暴食（BE）实验模型中的作用。方法。通过三个8天的禁食/再喂食周期以及在测试日（第25天）施加急性应激，诱发雌性大鼠对高适口性食物（HPF）的暴饮暴食行为。应激通过在15分钟内阻止大鼠获取HPF来诱导，此时大鼠能够看到和闻到HPF。通过灌胃给予贯叶连翘干提取物。结果。只有同时经历食物限制和应激的大鼠出现了暴饮暴食行为。250和500mg/kg剂量的贯叶连翘提取物显著减少了暴饮暴食发作次数，而125mg/kg剂量则无效。在没有暴饮暴食的情况下，相同剂量对HPF摄入量没有影响。250mg/kg剂量并未显著改变应激诱导的血清皮质酮水平升高，这表明对暴饮暴食的作用并非由于应激反应的抑制。125mg/kg的贯叶连翘与红景天的活性成分红景天苷联合给药，对暴饮暴食产生了协同作用。结论。目前的结果首次表明，贯叶连翘提取物可能对与暴饮暴食相关的饮食失调具有治疗作用。
