穴位埋线疗法不同穴位处方治疗支气管哮喘的对照研究

[Controlled study on different acupoint-prescription for the acupoint catgut embedding therapy in treatment of bronchial asthma].

作者信息

Chen Pan-Bi, Cui Jin, Yang Xiao-Fang

机构信息

Acupuncture-Moxibustion and Tuina College, Guiyang University of TCM, Guiyang 550002, Guizhou Province, China.

出版信息

Zhongguo Zhen Jiu. 2012 Jul;32(7):630-3.

PMID:22997795

Abstract

OBJECTIVE

To probe into the best acupoint-prescription for the simple acupoint catgut embedding therapy in treatment of bronchial asthma.

METHODS

Forty-eight Wistar rats were randomly divided into six groups: the simple acupoint catgut embedding at Feishu (BL 13), Danzhong (CV 17) and Shenshu (BL 23) group (group A), the simple acupoint catgut embedding at Shenshu (BL 23) group (group B), the simple acupoint catgut embedding at Feishu (BL 13) and Danzhong (CV 17) group (group C), Dexamethasone group (group D), model group (group E), and control group (group F), 8 rats in each group. The asthmatic models were established by Ovalbumin (OVA) except group F. Rats in group A, B and C were treated with catgut embedding at the corresponding acupoints from the first experimental day. In group E and D, Dexamethasone and sterile were intraperitoneal injected respectively from the 15th experimental day, once a day for 2 weeks consistantly. No interventions were added on group F. For the six groups, the symptoms of asthmatic attack were observed and the pathologic changes of lung tissue were examined.

RESULTS

(1) The times of sneeze and rhinocnesmus scratching nose in group E were increased significantly compared with those in group F (both P < 0.01), but there was no significant difference between group D and F (both P > 0.05). As compared with that in group E, except the times of sneeze in group C, the times mentioned above were decreased significantly in all the treatment groups (all P < 0.01). There was no significant difference between group A and D (both P > 0.05), but the times mentioned above were increased significantly in group B and C as compared with that in group A (all P < 0.01). (2) The symptoms of asthmatic attack and the pathologic changes of airway tissue were all alleviated in group A, B and C, but a better amelioration was observed in group A, with no mucus epistom in the bronchial lumen and few infiltrations of inflammatory cells around the bronchi.

CONCLUSION

The improvement of the simple acupoint catgut embedding at "Feishu" (BL 13), "Danzhong" (CV 17)and "Shenshu" (BL 23) on the airway inflammation in asthmatic rats is better than that of catgut embedding at "Feishu" (BL 13) and "Danzhong" (CV 17) or at "Shenshu" (BL 23) only.

摘要

目的

探讨单纯穴位埋线治疗支气管哮喘的最佳穴位配方。

方法

将48只Wistar大鼠随机分为6组：肺俞（BL 13）、膻中（CV 17）、肾俞（BL 23）单纯穴位埋线组（A组），肾俞（BL 23）单纯穴位埋线组（B组），肺俞（BL 13）、膻中（CV 17）单纯穴位埋线组（C组），地塞米松组（D组），模型组（E组），对照组（F组），每组8只。除F组外，其余各组均采用卵清蛋白（OVA）制备哮喘模型。A、B、C组大鼠从实验第1天起在相应穴位进行埋线治疗。E组和D组分别从实验第15天起腹腔注射地塞米松和生理盐水，每日1次，连续2周。F组不做任何干预。观察6组大鼠哮喘发作症状，并检测肺组织病理变化。

结果

（1）E组大鼠打喷嚏次数、鼻痒擦鼻次数较F组显著增加（均P < 0.01），D组与F组比较差异无统计学意义（均P > 0.05）。与E组比较，除C组打喷嚏次数外，各治疗组上述指标均显著降低（均P < 0.01）。A组与D组比较差异无统计学意义（均P > 0.05），但B组和C组上述指标较A组显著增加（均P < 0.01）。（2）A、B、C组哮喘发作症状及气道组织病理变化均有改善，但A组改善更明显，支气管腔内无黏液栓，支气管周围炎症细胞浸润较少。