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针灸治疗哮喘的机制与应用研究综述

Research on the Mechanism and Application of Acupuncture Therapy for Asthma: A Review.

作者信息

Wang Fei-Xuan, Jin Lu-Wei

机构信息

Department of Clinical Medical College, Qilu Medical College, Zibo, Shandong, People's Republic of China.

Department of Acupuncture and Tuina, Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou, Zhejiang, People's Republic of China.

出版信息

J Asthma Allergy. 2024 May 29;17:495-516. doi: 10.2147/JAA.S462262. eCollection 2024.

DOI:10.2147/JAA.S462262
PMID:38828396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11144428/
Abstract

Asthma is a high-risk disease based on airway hyperresponsiveness (AHR). In this review, we found that there are many studies on clinical therapy for asthma that focus on the efficacy of acupuncture therapy and its mechanisms, including the functional connectivity of different brain regions, with the aid of functional magnetic resonance imaging (fMRI), immune responses/cell recognition (innate lymphoid cells and balance of Th1/Th2 and Treg/Th17), intracellular mechanism (autophagy, endoplasmic reticulum stress, and epigenetic alteration), and ligand-receptor/chemical signaling pathway (neurotransmitter, hormone, and small molecules). In this review, we summarized the clinical and experimental evidence for the mechanisms of acupuncture therapy in asthma to offer insights into drug discovery and clinical therapy. Given the paucity of clinical studies on the mechanisms of acupuncture in the treatment of asthma, this review notably included studies based on animal models to investigate the mechanisms of acupuncture in the treatment of asthma.

摘要

哮喘是一种基于气道高反应性（AHR）的高危疾病。在本综述中，我们发现有许多关于哮喘临床治疗的研究聚焦于针刺疗法的疗效及其机制，包括借助功能磁共振成像（fMRI）研究不同脑区的功能连接、免疫反应/细胞识别（固有淋巴细胞以及Th1/Th2和Treg/Th17的平衡）、细胞内机制（自噬、内质网应激和表观遗传改变）以及配体-受体/化学信号通路（神经递质、激素和小分子）。在本综述中，我们总结了针刺疗法治疗哮喘机制的临床和实验证据，以期为药物研发和临床治疗提供见解。鉴于针刺治疗哮喘机制的临床研究较少，本综述特别纳入了基于动物模型的研究，以探究针刺治疗哮喘的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/e574d6a4c850/JAA-17-495-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/7634a89f91be/JAA-17-495-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/56c5b9e262c9/JAA-17-495-g0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/d7ccc4696df1/JAA-17-495-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/e574d6a4c850/JAA-17-495-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/7634a89f91be/JAA-17-495-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/56c5b9e262c9/JAA-17-495-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/20655a1793fe/JAA-17-495-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/4cb593e3640f/JAA-17-495-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/d7ccc4696df1/JAA-17-495-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bad/11144428/e574d6a4c850/JAA-17-495-g0006.jpg

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本文引用的文献

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2
The Burden of Asthma and Allergic Rhinitis: Epidemiology and Health Care Costs.哮喘和过敏性鼻炎的负担：流行病学和医疗保健成本。
Otolaryngol Clin North Am. 2024 Apr;57(2):179-189. doi: 10.1016/j.otc.2023.09.007. Epub 2023 Oct 11.
3
Clinical Subtypes of Neutrophilic Asthma: A Cluster Analysis From Australasian Severe Asthma Network.嗜中性粒细胞性哮喘的临床亚型：来自澳大拉西亚重症哮喘网络的聚类分析
J Allergy Clin Immunol Pract. 2024 Mar;12(3):686-698.e8. doi: 10.1016/j.jaip.2023.09.023. Epub 2023 Sep 29.
4
A network meta-analysis of different acupuncture modalities in the treatment of bronchial asthma.不同针刺方式治疗支气管哮喘的网状Meta 分析。
BMC Pulm Med. 2023 Sep 22;23(1):357. doi: 10.1186/s12890-023-02645-8.
5
Clinical evidence for acupuncture for adult asthma: Systematic review and meta-analysis of randomised sham/placebo-controlled trials.针刺治疗成人哮喘的临床证据：随机假针刺/安慰剂对照试验的系统评价和荟萃分析。
Complement Ther Med. 2023 Aug;75:102956. doi: 10.1016/j.ctim.2023.102956. Epub 2023 May 29.
6
Factors Associated with the Use of Complementary and Alternative Medicine/Therapy among United States Adults with Asthma.美国成年哮喘患者使用补充和替代医学/疗法的相关因素。
Healthcare (Basel). 2023 Mar 30;11(7):983. doi: 10.3390/healthcare11070983.
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Trends in the Use of Complementary and Alternative Therapies among US Adults with Current Asthma.美国成年哮喘患者使用补充和替代疗法的趋势。
Epidemiologia (Basel). 2023 Mar 21;4(1):94-105. doi: 10.3390/epidemiologia4010010.
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