Ahn Jiyoung, Abnet Christian C, Cross Amanda J, Sinha Rashmi
NYU School of Medicine, New York, NY, USA.
IARC Sci Publ. 2011(163):189-98.
Though dietary factors are implicated in chronic disease risk, assessment of dietary intake has limitations, including problems with recall of complex food intake patterns over a long period of time. Diet and nutrient biomarkers may provide objective measures of dietary intake and nutritional status, as well as an integrated measure of intake, absorption and metabolism. Thus, the search for an unbiased biomarker of dietary intake and nutritional status is an important aspect of nutritional epidemiology. This chapter reviews types of biomarkers related to dietary intake and nutritional status, such as exposure biomarkers of diet and nutritional status, intermediate endpoints, and susceptibility. Novel biomarkers, such as biomarkers of physical fitness, oxidative DNA damage and tissue concentrations are also discussed.
尽管饮食因素与慢性病风险有关，但饮食摄入量评估存在局限性，包括难以长期回忆复杂的食物摄入模式。饮食和营养生物标志物可以提供饮食摄入量和营养状况的客观指标，以及摄入量、吸收和代谢的综合指标。因此，寻找无偏差的饮食摄入量和营养状况生物标志物是营养流行病学的一个重要方面。本章回顾了与饮食摄入量和营养状况相关的生物标志物类型，如饮食和营养状况的暴露生物标志物、中间终点和易感性。还讨论了新型生物标志物，如体能生物标志物、氧化性DNA损伤和组织浓度。
