一个关于患者选择如何影响多形性胶质母细胞瘤生存率的例子。
An example of how patient selection can influence survival in glioblastoma multiforme.
作者信息
Gilbert H A, Cassidy F, Wagner J, Eder D, Kagan A R, Cove J K
出版信息
Cancer Clin Trials. 1978 Summer;1(2):103-5.
PMID:229979
Abstract
Drawing on experience in evaluating postsurgical treatment of glioblastoma multiforme, it is concluded that results of clinical trials programs can be greatly affected by the status of patients who are selected for study. Investigations report results only on patients considered "evaluable," a portion of the total which may be less than 20%. Improvement in patient survival should not be conceived to be due to aggressive treatment unless patient selection has been accounted for.
摘要
借鉴评估多形性胶质母细胞瘤术后治疗的经验，得出的结论是，临床试验项目的结果可能会受到所选研究患者状况的极大影响。研究报告仅针对被认为“可评估”的患者的结果，这部分患者占总数的比例可能不到20%。除非考虑了患者选择因素，否则不应认为患者生存率的提高是积极治疗的结果。
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