Ishii J, Nakanishi K, Shimada K
Dept. of Oral Surgery, Kobe Univ., School of Med.
Gan No Rinsho. 1990 Jan;36(1):66-70.
Most malignancies occurring in the oral cavity are squamous carcinoma for which radiotherapy as a treatment is the first choice. However, radiostomatitis, which occurs as a concomitant symptom due to radiation, largely disturbs the effect of radiotherapy. Antibiotics or a gargle are used to treat this concomitant symptom, but these preparations are not satisfactorily effective especially in cases in which the symptoms are severe and/or wide spread. Salcoat, a spray-type preparation of Beclomethasone dipropionate that is used to treat stomatitis, has excellent features which compensate for the disadvantage of the previously mentioned therapy. This preparation can be administered in a non-contact manner, and it contains hydroxypropyl cellulose which assures good adhesion to the mucosa, thus covering and protecting the affected area for a long time. In our clinical trials, this preparation was found to be highly useful in relieving pain and dysgeusia due to radiostomatitis, there by maintaining the quality of life.
发生在口腔的大多数恶性肿瘤是鳞状细胞癌，放射治疗是其首选治疗方法。然而，作为放疗伴随症状出现的放射性口炎在很大程度上干扰了放疗效果。抗生素或漱口水被用于治疗这种伴随症状，但这些制剂效果并不理想，尤其是在症状严重和/或广泛扩散的情况下。用于治疗口炎的丙酸倍氯米松喷雾型制剂Salcoat具有优异的特性，弥补了上述治疗方法的不足。该制剂可以非接触方式给药，并且含有羟丙基纤维素，可确保与粘膜良好粘附，从而长时间覆盖和保护受影响区域。在我们的临床试验中，发现该制剂在缓解放射性口炎引起的疼痛和味觉障碍方面非常有用，从而维持生活质量。
