Ankara University Faculty of Medicine, Pathophysiology Department, Morphology Building, 06100 Sihhiye, Ankara, Turkey.
Curr Drug Deliv. 2013 Feb;10(1):54-7. doi: 10.2174/1567201811310010009.
Midkine (MK) is a member of midkine family which is composed of MK and pleotrophin (PTN). MK behaves like a cytokine and growth factor, promotes the proliferation, differentiation, survival, adhesion, migration of cells. MK expression usually increases during ischemia, inflammation, tissue repair, neoplastic transformation and in different toxic conditions. Immune cells and most of organs have MK secretion function in fetal and adult life. MK could be a promising prognostic/diagnostic marker and a potential target in many of diseases including malignancy, toxic and inflammatory diseases. This review focuses on both cell protective and immune-modulatory roles of MK in different in vitro and in vivo disease models and human reports. MK is still a novel molecule in the regulation of organ development and the etiology of many diseases.
中期因子（MK）是中期因子家族的一员，该家族由 MK 和多效蛋白（PTN）组成。MK 具有细胞因子和生长因子的作用，可促进细胞的增殖、分化、存活、黏附和迁移。MK 的表达通常在缺血、炎症、组织修复、肿瘤转化和不同的毒性条件下增加。在胎儿和成人期，免疫细胞和大多数器官都具有 MK 的分泌功能。MK 可能是许多疾病（包括恶性肿瘤、毒性和炎症性疾病）中很有前途的预后/诊断标志物和潜在治疗靶点。本文综述了 MK 在不同的体外和体内疾病模型及人类研究中的细胞保护和免疫调节作用。MK 仍然是调节器官发育和许多疾病病因的一个新分子。
