Department of Neurology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sweden.
Acta Neurol Scand. 2013 Feb;127(2):e8-12. doi: 10.1111/ane.12012. Epub 2012 Sep 23.
Low levels of serum urate are associated with a higher risk of Parkinson's disease (PD). Higher serum and cerebrospinal fluid (CSF) urate levels are associated with slower rates of clinical decline in PD and in multiple system atrophy (MSA).
To compare CSF and blood urate levels in healthy controls, patients with synucleinopathies and with tauopathies.
We investigated urate levels in serum and CSF from 18 healthy controls, 19 patients with synucleinopathies (six patients with PD and 13 with MSA), and 24 patients with tauopathies (18 with progressive supranuclear palsy and six with corticobasal degeneration). None of the patients were treated with dopaminergic medications.
No significant differences were seen when comparing serum and CSF urate levels from controls across the parkinsonian diagnostic groups. However, in men, serum urate levels were significantly lower in the synucleinopathy group compared with the tauopathy group (P = 0.046), although with a broad overlap.
Our study suggests that urate levels might provide new insights into the potential pathophysiological mechanisms underlying Parkinsonism and thereby contribute to the future management of these disorders.
血清尿酸水平较低与帕金森病（PD）的风险增加相关。较高的血清和脑脊液（CSF）尿酸水平与 PD 和多系统萎缩（MSA）患者的临床下降速度较慢相关。
比较健康对照组、突触核蛋白病患者和tau 病患者的 CSF 和血液尿酸水平。
我们研究了来自 18 名健康对照者、19 名突触核蛋白病患者（6 名 PD 患者和 13 名 MSA 患者）和 24 名 tau 病患者（18 名进行性核上性麻痹和 6 名皮质基底节变性）的血清和 CSF 中的尿酸水平。这些患者均未接受多巴胺能药物治疗。
在比较帕金森诊断组之间的健康对照组的血清和 CSF 尿酸水平时，没有发现显著差异。然而，在男性中，与 tau 病组相比，突触核蛋白病组的血清尿酸水平显著降低（P = 0.046），尽管存在广泛重叠。
我们的研究表明，尿酸水平可能为帕金森病潜在的病理生理机制提供新的见解，并为这些疾病的未来治疗提供帮助。
