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酒精摄入量、血液酒精水平以及体重在实验设计与分析中的相关性。

Alcohol consumption, blood alcohol level and the relevance of body weight in experimental design and analysis.

作者信息

Devgun M S, Dunbar J A

机构信息

Department of Biochemistry, Law Hospital, Carluke, Lanarkshire, Scotland.

出版信息

J Stud Alcohol. 1990 Jan;51(1):24-8. doi: 10.15288/jsa.1990.51.24.

DOI:10.15288/jsa.1990.51.24
PMID:2299845
Abstract

In healthy male subjects, intake of alcohol is not closely related to body weight although there is a significant correlation between consumption and body weight in the younger age group. No association was observed between age and alcohol consumption. Age did show a significant association when expressed in terms of intake per weight. Eight hours after consumption blood alcohol did not vary significantly in people with different body weight; total body water is probably the key factor. This study raises doubts about experimental designs and calculations of blood alcohol whereby assumption is made that correcting alcohol dose for body weight would give precise information. Conclusions from such studies could in fact be misleading.

摘要

在健康男性受试者中,酒精摄入量与体重并无密切关联,尽管在较年轻年龄组中,饮酒量与体重之间存在显著相关性。未观察到年龄与酒精摄入量之间存在关联。然而,按每体重摄入量来表示时,年龄确实显示出显著关联。饮酒8小时后,不同体重的人血液酒精含量并无显著差异;总体水含量可能是关键因素。这项研究对血液酒精含量的实验设计和计算提出了质疑,因为这些设计和计算假定根据体重校正酒精剂量就能得出精确信息。事实上,此类研究得出的结论可能具有误导性。

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