Whitfield J B, Martin N G
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown NSW, Australia.
Alcohol Clin Exp Res. 1994 Apr;18(2):238-43. doi: 10.1111/j.1530-0277.1994.tb00007.x.
We have analyzed the interrelationships between habitual alcohol consumption, peak blood alcohol concentration after a standard dose, and rate of alcohol metabolism in a group of 199 male and 213 female twins. Both peak concentration and rate of metabolism are strongly associated with alcohol consumption levels, even in the range of 0-10 g of alcohol/day. The peak concentration and rate of metabolism were strongly correlated in both men and women; this is not due to their common dependence on alcohol intake nor to experimental error. These results show that the threshold for effects of habitual consumption on alcohol pharmacokinetics is much lower than previously suspected, and that there are factors that reduce preabsorptive or first-pass metabolism but increase postabsorptive metabolism.
我们分析了199名男性和213名女性双胞胎群体中习惯性饮酒、标准剂量后血液酒精浓度峰值以及酒精代谢率之间的相互关系。即使在每天饮酒0 - 10克的范围内，峰值浓度和代谢率都与饮酒水平密切相关。男性和女性的峰值浓度与代谢率都高度相关；这既不是由于它们对酒精摄入量的共同依赖，也不是由于实验误差。这些结果表明，习惯性饮酒对酒精药代动力学产生影响的阈值比之前怀疑的要低得多，并且存在一些因素会降低吸收前或首过代谢，但会增加吸收后代谢。
