University of North Carolina, Chapel Hill, NC, USA.
Am J Intellect Dev Disabil. 2012 Sep;117(5):384-99. doi: 10.1352/1944-7558-117.5.384.
Verbal perseveration is a frequently reported language characteristic of males with Fragile X syndrome and may be a defining feature or hallmark of the syndrome. We compared the verbal perseveration of boys with Fragile X syndrome with (n = 29) and without (n = 30) autism spectrum disorder, boys with Down syndrome (n = 27), and typically developing boys (n = 25) at similar nonverbal mental ages. During a social interaction, boys with both Fragile X syndrome and autism spectrum disorder produced significantly more topic perseveration than all other groups. In social interaction as compared to narration, boys with Fragile X syndrome (regardless of autism status) produced significantly more topic perseveration. These findings suggest that autism status, as well as language sampling context, affect perseveration in boys with Fragile X syndrome.
言语持续是脆性 X 综合征男性患者经常出现的语言特征，可能是该综合征的一个特征或标志。我们比较了脆性 X 综合征伴有（n=29）和不伴有（n=30）自闭症谱系障碍、唐氏综合征（n=27）以及发育正常的男孩（n=25）的言语持续，这些男孩的非言语智力年龄相近。在社会互动中，脆性 X 综合征和自闭症谱系障碍男孩的话题持续时间明显长于其他所有组。与叙述相比，在社会互动中，脆性 X 综合征男孩（无论自闭症状态如何）的话题持续时间明显更长。这些发现表明，自闭症状态以及语言取样环境会影响脆性 X 综合征男孩的持续行为。
