Northwestern University, USA.
Am J Intellect Dev Disabil. 2013 Mar;118(2):77-94. doi: 10.1352/1944-7558-118.2.77.
Whereas pragmatic language difficulties are characteristic of both autism and Fragile X syndrome, it is unclear whether such deficits are qualitatively similar or whether certain skills are differentially affected. This study compared narrative competence in boys with autism, Fragile X syndrome, Down syndrome, and typical development. Results revealed that an interaction between diagnosis and nonverbal mental age predicted narrative microstructure (e.g., complex syntax) but not macrostructure (e.g., thematic maintenance). Correlations with FMR1-related variation were investigated in children with Fragile X syndrome. While CGG repeat length was associated with many language characteristics, nonverbal IQ appeared to mediate these relationships. These findings are an important step toward understanding narrative abilities in boys with and without the FMR1 mutation.
虽然语用语言困难是自闭症和脆性 X 综合征的共同特征,但这些缺陷在性质上是否相似,或者某些技能是否受到不同程度的影响,尚不清楚。本研究比较了自闭症、脆性 X 综合征、唐氏综合征和典型发育男孩的叙事能力。结果表明,诊断和非言语智力年龄的相互作用预测了叙事的微观结构(例如,复杂语法),但不预测宏观结构(例如,主题维持)。还研究了脆性 X 综合征儿童与 FMR1 相关变异的相关性。尽管 CGG 重复长度与许多语言特征相关,但非言语智商似乎介导了这些关系。这些发现是理解脆性 X 综合征男孩和无脆性 X 综合征男孩叙事能力的重要一步。