Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
J Am Chem Soc. 2012 Oct 10;134(40):16492-5. doi: 10.1021/ja307210n. Epub 2012 Sep 26.
Catalytic bromolactonization of long-chain olefinic acids resulting in the efficient synthesis of medium-sized lactones is reported using a zwitterionic catalyst and stoichiometric N-bromosuccinimide halogen source. The reaction was found to be more efficient at 0 °C than at room temperature, which could be attributed to the temperature dependence of the zwitterionic catalyst.
本文报道了一种使用两性离子催化剂和化学计量的 N-溴代丁二酰亚胺卤源，实现长链烯酸催化溴内酯化，从而高效合成中到大环内酯的方法。研究发现，该反应在 0°C 下比在室温下更为有效，这可能归因于两性离子催化剂的温度依赖性。
