Li Caicui, Cheng Yao, Pang Fudan, Yan Xiushuo, Huang Zhengtao, Wang Xinmei, Wang Xiaodan, Li Yiying, Wang Jinhui, Xu Huanjun
Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University Harbin China
School of Science, Qiongtai Normal University Haikou 571127 China
RSC Adv. 2025 Mar 19;15(11):8523-8528. doi: 10.1039/d5ra00837a. eCollection 2025 Mar 17.
A simple, efficient and environmentally friendly methodology for the halodecarboxylation of anisole analogues using Fe(NO)·9HO/KBr or NaI at room temperature was developed. In this method, most substrates with an electron-donating group afforded corresponding products in good to excellent yields, whereas those with an electron-withdrawing group afforded low to moderate yields. More importantly, this protocol was also applicable for gram-scale synthesis. It is hoped that this methodology will be highly useful in organic synthesis.
开发了一种简单、高效且环境友好的方法，用于在室温下使用Fe(NO)₃·9H₂O/KBr或NaI对苯甲醚类似物进行卤代脱羧反应。在该方法中，大多数带有供电子基团的底物能以良好至优异的产率得到相应产物，而那些带有吸电子基团的底物产率则较低至中等。更重要的是，该方案也适用于克级规模的合成。希望这种方法在有机合成中会非常有用。
