Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Am J Med. 2012 Oct;125(10):974-80. doi: 10.1016/j.amjmed.2012.03.008.
There are no previous studies investigating the effect of all dietary antioxidants in relation to myocardial infarction. The total antioxidant capacity of diet takes into account all antioxidants and synergistic effects between them. The aim of this study was to examine how total antioxidant capacity of diet and antioxidant-containing foods were associated with incident myocardial infarction among middle-aged and elderly women.
In the population-based prospective Swedish Mammography Cohort of 49-83-year-old women, 32,561 were cardiovascular disease-free at baseline. Women completed a food-frequency questionnaire, and dietary total antioxidant capacity was calculated using oxygen radical absorbance capacity values. Information on myocardial infarction was identified from the Swedish Hospital Discharge and the Cause of Death registries. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Cox proportional hazard models.
During the follow-up (September 1997-December 2007), we identified 1114 incident cases of myocardial infarction (321,434 person-years). In multivariable-adjusted analysis, the HR for women comparing the highest quintile of dietary total antioxidant capacity to the lowest was 0.80 (95% CI, 0.67-0.97; P for trend=0.02). Servings of fruit and vegetables and whole grains were nonsignificantly inversely associated with myocardial infarction.
These data suggest that dietary total antioxidant capacity, based on fruits, vegetables, coffee, and whole grains, is of importance in the prevention of myocardial infarction.
目前尚无研究调查饮食中所有抗氧化剂与心肌梗死之间的关系。饮食中的总抗氧化能力考虑了所有的抗氧化剂及其协同作用。本研究旨在探讨饮食中的总抗氧化能力和含抗氧化剂的食物与中老年女性心肌梗死事件之间的关系。
在基于人群的瑞典乳腺 X 线摄影队列中，纳入了 49-83 岁心血管疾病初发的 49,831 名女性。女性完成了食物频率问卷，使用氧自由基吸收能力值计算饮食中的总抗氧化能力。心肌梗死的信息来源于瑞典住院和死因登记。使用 Cox 比例风险模型计算危险比（HR）和 95%置信区间（CI）。
在随访期间（1997 年 9 月至 2007 年 12 月），我们共发现了 1114 例心肌梗死事件（321,434 人年）。在多变量调整分析中，与最低五分位数相比，饮食总抗氧化能力最高五分位数的女性 HR 为 0.80（95%CI，0.67-0.97；趋势 P 值=0.02）。水果和蔬菜以及全谷物的摄入量与心肌梗死呈负相关，但无统计学意义。
这些数据表明，基于水果、蔬菜、咖啡和全谷物的饮食总抗氧化能力对预防心肌梗死具有重要意义。
