结直肠癌的大部分遗传风险可能是通过对腺瘤的易感性来介导的。
Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
机构信息
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
出版信息
Gastroenterology. 2013 Jan;144(1):53-5. doi: 10.1053/j.gastro.2012.09.016. Epub 2012 Sep 19.
Abstract
Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not associated significantly with adenoma risk. Genetic susceptibility to CRC in the general population is likely to be mediated in part by predisposition to adenomas.
摘要
一些单核苷酸多态性（SNPs）与结直肠癌（CRC）易感性相关。大多数 CRC 源自腺瘤，因此 SNPs 可能通过增加腺瘤风险来影响 CRC 的易感性。我们发现，与对照组相比，18 个已知的 CRC 相关 SNPs（rs10936599、rs6983267、rs10795668、rs3802842、rs4444235、rs1957636、rs4939827 和 rs961253）在无 CRC 的腺瘤患者中过度表达。另外 10 个与 CRC 相关的 SNPs（rs6691170、rs6687758、rs16892766、rs7136702、rs11169552、rs4779584、rs9929218、rs10411210、rs4813802 和 rs4925386）与腺瘤风险无显著相关性。一般人群中 CRC 的遗传易感性可能部分通过对腺瘤的易感性来介导。
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