在 3T 场强下测量体内 GABA 的纵向弛豫时间。
Measuring the longitudinal relaxation time of GABA in vivo at 3 Tesla.
机构信息
Russel H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
出版信息
J Magn Reson Imaging. 2013 Apr;37(4):999-1003. doi: 10.1002/jmri.23817. Epub 2012 Sep 21.
Abstract
PURPOSE
To measure the in vivo longitudinal relaxation time T1 of GABA at 3 Tesla (T).
MATERIALS AND METHODS
J-difference edited single-voxel MR spectroscopy was used to isolate γ-aminobutyric acid (GABA) signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing-based suppression of co-edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in 10 healthy participants, a saturation-recovery equation was used to model the integrated data.
RESULTS
The longitudinal relaxation time of GABA was measured as T(1,GABA) = 1.31 ± 0.16 s.
CONCLUSION
The method described has been successfully applied to measure the T1 of GABA in vivo at 3T.
摘要
目的
在 3 特斯拉（T）下测量 GABA 的体内纵向弛豫时间 T1。
材料与方法
使用 J 差编辑单体素磁共振波谱技术来分离 γ-氨基丁酸（GABA）信号。采用增加的回波时间（80ms）采集，以适应基于对称编辑的共编辑大分子信号抑制所需的更长、更具选择性的编辑脉冲。在 10 名健康参与者中，在一系列弛豫时间下采集编辑 GABA 测量值，使用饱和恢复方程对整合数据进行建模。
结果
测量 GABA 的纵向弛豫时间为 T（1，GABA）= 1.31±0.16s。
结论
所描述的方法已成功应用于在 3T 下测量体内 GABA 的 T1。
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2
In vivo magnetic resonance spectroscopy of GABA: a methodological review.
Prog Nucl Magn Reson Spectrosc. 2012 Jan;60:29-41. doi: 10.1016/j.pnmrs.2011.06.001. Epub 2011 Jun 12.
3
Regionally specific human GABA concentration correlates with tactile discrimination thresholds.
J Neurosci. 2011 Nov 16;31(46):16556-60. doi: 10.1523/JNEUROSCI.4489-11.2011.
4
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J Magn Reson Imaging. 2012 Jan;35(1):229-34. doi: 10.1002/jmri.22865. Epub 2011 Nov 1.
5
Dorsolateral prefrontal γ-aminobutyric acid in men predicts individual differences in rash impulsivity.
Biol Psychiatry. 2011 Nov 1;70(9):866-72. doi: 10.1016/j.biopsych.2011.05.030. Epub 2011 Jul 14.
6
Individual variability in the shape and amplitude of the BOLD-HRF correlates with endogenous GABAergic inhibition.
Hum Brain Mapp. 2012 Feb;33(2):455-65. doi: 10.1002/hbm.21223. Epub 2011 Mar 17.
7
Efficient γ-aminobutyric acid editing at 3T without macromolecule contamination: MEGA-SPECIAL.
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8
Relating MEG measured motor cortical oscillations to resting γ-aminobutyric acid (GABA) concentration.
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9
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