在 7T 下测定人脑内 GABA 的体内横向弛豫时间。
Determining the in vivo transverse relaxation time of GABA in the human brain at 7T.
机构信息
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
J Magn Reson Imaging. 2013 Nov;38(5):1224-9. doi: 10.1002/jmri.23979. Epub 2012 Dec 13.
PURPOSE
To measure in vivo transverse relaxation times (T2 ) of gamma-aminobutyric acid (GABA) at 7T using the experimental spectral-editing method.
MATERIALS AND METHODS
Experiments were performed at 7T in a 10 mM GABA phantom to determine the intrinsic TE-dependence of the edited signal. Then the same method was applied with editing-based suppression of coedited macromolecular signals to five healthy volunteers to determine T2 of GABA in vivo.
RESULTS
From in vivo data acquired at multiple echo times, the in vivo GABA T2 relaxation time was estimated to be 63 ± 19 msec.
CONCLUSION
We present a measurement of the T2 of edited GABA signal at 7T by first using phantom measurements to determine the echo time-dependence of edited signal. The method is purely experimental and does not rely on prior knowledge of coupling constants or simulation of realistic experiments. J. Magn. Reson. Imaging 2013;38:1224-1229. © 2013 Wiley Periodicals, Inc.
目的
使用实验性谱编辑方法测量 7T 下γ-氨基丁酸（GABA）的横向弛豫时间（T2）。
材料与方法
在 7T 下，于 10mM GABA 模型中进行实验，以确定编辑信号的固有 TE 依赖性。然后，使用基于编辑的共编辑大分子信号抑制方法，对五名健康志愿者进行同样的方法，以确定体内 GABA 的 T2。
结果
从多个回波时间获得的体内数据中，体内 GABA T2 弛豫时间估计为 63±19msec。
结论
我们通过首先使用体模测量来确定编辑信号的回波时间依赖性，来呈现 7T 下编辑 GABA 信号 T2 的测量方法。该方法是纯粹的实验性的，不依赖于耦合常数的先验知识或实际实验的模拟。J. Magn. Reson. Imaging 2013;38:1224-1229. © 2013 Wiley Periodicals, Inc.
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