Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 715 Sumter, Columbia, SC 29208, USA.
Adv Mater. 2012 Dec 18;24(48):6479-83. doi: 10.1002/adma.201202687. Epub 2012 Sep 24.
A nano cocktail, NCPD, fabricated from a pH and redox dual responsive polymer shows a multicompartment structure. The NCPD nanogel is stable in physiological environments while intracellular spontaneous swelling and fast releasing its payload. NCPD displays much stronger synergism than its free drug counterpart, which suggests that NCPD could greatly attenuate the side effects of drug cocktails while boosting synergistic anticancer effects.
一种由 pH 和氧化还原双重响应聚合物制备的纳米鸡尾酒 NCPD 呈现出多隔室结构。NCPD 纳米凝胶在生理环境中稳定，同时在细胞内自发肿胀并快速释放其有效载荷。NCPD 显示出比游离药物更强的协同作用，这表明 NCPD 可以在增强协同抗癌作用的同时，大大减轻药物鸡尾酒的副作用。
