Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, School of Materials and Energy, Southwest University, Chongqing 400715, P. R. China.
Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, P. R. China.
ACS Appl Mater Interfaces. 2021 Feb 24;13(7):8940-8951. doi: 10.1021/acsami.0c21710. Epub 2021 Feb 10.
Chemotherapy is currently the most universal therapeutics to tumor treatment; however, limited curative effect and undesirable drug resistance effect are the two major clinical bottlenecks. Herein, we develop a two-in-one cross-linking strategy to prepare a stimuli-responsive prodrug nanogel by virtue of delivering a combination of chemotherapeutic drugs of 10-hydroxy camptothecin and doxorubicin for ameliorating the deficiencies of chemotherapy and amplifying the cancer therapeutic efficiency. The obtained prodrug nanogel has both high drug loading capacity and suitable nanoscale size, which are beneficial to the cell uptake and tumor penetration. Moreover, the chemotherapeutic drugs are released from the prodrug nanogel in response to the reductive tumor microenvironment, enhancing tumor growth inhibition and by the synergistic DNA damage. Based on these results, the unique prodrug nanogel would be a promising candidate for satisfactory tumor treatment-based chemotherapy by a simple but efficient strategy.
化疗是目前治疗肿瘤最普遍的疗法；然而，疗效有限和不理想的耐药性是两个主要的临床瓶颈。在这里，我们开发了一种双交联策略，通过递送 10-羟基喜树碱和阿霉素的联合化疗药物来制备一种对刺激反应的前药纳米凝胶，以改善化疗的不足并放大癌症治疗效果。所得的前药纳米凝胶具有高载药量和合适的纳米级尺寸，有利于细胞摄取和肿瘤渗透。此外，前药纳米凝胶中的化疗药物在还原肿瘤微环境的响应下释放，通过协同的 DNA 损伤增强肿瘤生长抑制。基于这些结果，这种独特的前药纳米凝胶将是一种有前途的候选药物，通过一种简单但有效的策略实现令人满意的肿瘤治疗化疗。
