基于超支化聚甘油的阿霉素负载多响应纳米凝胶的一锅法合成
One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol.
作者信息
Sousa-Herves Ana, Wedepohl Stefanie, Calderón Marcelo
机构信息
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.
出版信息
Chem Commun (Camb). 2015 Mar 28;51(25):5264-7. doi: 10.1039/c5cc00644a.
Doxorubicin-loaded nanogels with multiresponsive properties are prepared using hyperbranched polyglycerol as a biocompatible scaffold. The nanogels are synthesized in a single step combining free-radical polymerization and a mild nanoprecipitation technique. The nanogels respond to different biological stimuli such as low pH and reductive environments, resulting in a more efficient cell proliferation inhibition in A549 cells.
以超支化聚甘油为生物相容性支架制备具有多响应特性的载阿霉素纳米凝胶。通过将自由基聚合与温和的纳米沉淀技术相结合，一步合成纳米凝胶。这些纳米凝胶对低pH和还原环境等不同生物刺激有响应，从而在A549细胞中产生更有效的细胞增殖抑制作用。
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