Thorp J M, White G C, Moake J L, Bowes W A
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill.
Obstet Gynecol. 1990 Feb;75(2):163-7.
The clinical manifestations of severe preeclampsia and thrombotic thrombocytopenic purpura are similar. Patients with thrombotic thrombocytopenic purpura have been demonstrated to have larger than usual von Willebrand factor multimers. Serial serum samples were taken from patients with severe preeclampsia, all with platelet counts less than 50,000. Von Willebrand factor multimeric patterns were normal in all the patients except one, who later proved to have chronic relapsing thrombotic thrombocytopenic purpura. All patients had elevated levels of von Willebrand factor. Although the clinical presentations of thrombotic thrombocytopenic purpura and severe preeclampsia with thrombocytopenia have many similarities, the underlying pathophysiology of each disorder appears to be different.
重度子痫前期和血栓性血小板减少性紫癜的临床表现相似。已证实血栓性血小板减少性紫癜患者的血管性血友病因子多聚体比正常情况更大。对重度子痫前期且血小板计数均低于50,000的患者采集了系列血清样本。除1例患者外，所有患者的血管性血友病因子多聚体模式均正常，该例患者后来被证实患有慢性复发性血栓性血小板减少性紫癜。所有患者的血管性血友病因子水平均升高。尽管血栓性血小板减少性紫癜与伴有血小板减少的重度子痫前期的临床表现有许多相似之处，但每种疾病的潜在病理生理学似乎有所不同。
