精神分裂症的医疗决策中应测量哪些非传统结局？系统评价。
Which nontraditional outcomes should be measured in healthcare decision-making in schizophrenia? A systematic review.
机构信息
Health Economics and Outcomes Research Department, IMS, Barcelona, Spain.
出版信息
Perspect Psychiatr Care. 2012 Oct;48(4):198-207. doi: 10.1111/j.1744-6163.2011.00325.x. Epub 2012 Feb 7.
PURPOSE
This article aims to define the utility of nontraditional outcomes (NTOs) in healthcare decision-making in schizophrenia.
DESIGN AND METHODS
A systematic review of studies published between January 1, 1996, and December 31, 2008, was performed. A 10-point evidence-based utility index (UI) was used to assess the utility of NTOs: high (UI: 7.5-10), medium (UI: ≥ 5 to <7.5), and low (UI: <5) utility.
FINDINGS
Of 736 citations identified, 94 met inclusion criteria. One hundred ninety-four NTOs were identified (patient reported outcomes [38.7%] and economic outcomes [61.3%]). Of these, 68 (35.1%) were appropriate for decision making.
PRACTICE IMPLICATIONS
Numerous NTOs with low utility in schizophrenia are being used for healthcare policy and clinical care by policy makers, managers, and healthcare professionals. Medium and low utility NTOs should be used with caution.
目的
本文旨在确定非传统结局（NTOs）在精神分裂症医疗决策中的应用价值。
设计与方法
对 1996 年 1 月 1 日至 2008 年 12 月 31 日期间发表的研究进行了系统评价。采用 10 分基于证据的效用指数（UI）来评估 NTOs 的效用：高（UI：7.5-10）、中（UI：≥5 至 <7.5）和低（UI：<5）效用。
结果
在 736 篇引文中共纳入 94 项研究。共确定了 194 个 NTOs（患者报告结局[38.7%]和经济结局[61.3%]）。其中，68 个（35.1%）适用于决策。
实践意义
决策者、管理者和医疗保健专业人员正在将大量具有低效用的 NTOs 用于医疗保健政策和临床护理。中效和低效 NTOs 的使用应慎重。
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