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一群造血丝氨酸蛋白酶基因与人类α/δ T细胞受体基因座位于同一条染色体带上。

A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.

作者信息

Hanson R D, Hohn P A, Popescu N C, Ley T J

机构信息

Department of Medicine, Jewish Hospital at Washington University Medical Center, St. Louis, MO 63110.

出版信息

Proc Natl Acad Sci U S A. 1990 Feb;87(3):960-3. doi: 10.1073/pnas.87.3.960.

DOI:10.1073/pnas.87.3.960
PMID:2300587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC53389/
Abstract

The chymotrypsin-like family of serine protease genes includes several members that are expressed exclusively in subsets of hematopoietic cells. For example, human neutrophil elastase and cathepsin G are expressed only in myelomonocytic precursors, and cytotoxic-T-cell serine proteases are found only in cytotoxic lymphocytes. We have used a cathepsin G cDNA probe to clone two cathepsin G-like genes (designated CGL-1 and CGL-2) from a human genomic library. We have determined that CGL-1 is identical to a previously identified gene (known as CCPI, CTLA I, or cytotoxic serine protease B) that is expressed only in activated cytotoxic T lymphocytes. We show here that cathepsin G, CGL-1, and CGL-2 are linked on an approximately 50-kilobase locus found on human chromosome 14 at band q11.2. This gene cluster maps to the same chromosomal band as the alpha and delta T-cell receptor genes; this region is involved in most chromosomal translocations and inversions that are specifically associated with T-cell malignancies.

摘要

丝氨酸蛋白酶基因的类胰凝乳蛋白酶家族包括几个仅在造血细胞亚群中表达的成员。例如，人中性粒细胞弹性蛋白酶和组织蛋白酶G仅在髓单核细胞前体中表达，而细胞毒性T细胞丝氨酸蛋白酶仅在细胞毒性淋巴细胞中发现。我们使用组织蛋白酶G cDNA探针从人基因组文库中克隆了两个类组织蛋白酶G基因（命名为CGL-1和CGL-2）。我们确定CGL-1与先前鉴定的一个基因（称为CCPI、CTLA I或细胞毒性丝氨酸蛋白酶B）相同，该基因仅在活化的细胞毒性T淋巴细胞中表达。我们在此表明，组织蛋白酶G、CGL-1和CGL-2在人类14号染色体q11.2带的一个约50千碱基的位点上连锁。该基因簇定位于与α和δ T细胞受体基因相同的染色体带；该区域涉及大多数与T细胞恶性肿瘤特异性相关的染色体易位和倒位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed42/53389/45dd06b8b722/pnas01028-0114-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed42/53389/d0fcc88cf8c6/pnas01028-0113-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed42/53389/34661d7bca7f/pnas01028-0113-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed42/53389/1498287b0cd4/pnas01028-0113-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed42/53389/45dd06b8b722/pnas01028-0114-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed42/53389/d0fcc88cf8c6/pnas01028-0113-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed42/53389/34661d7bca7f/pnas01028-0113-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed42/53389/1498287b0cd4/pnas01028-0113-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed42/53389/45dd06b8b722/pnas01028-0114-a.jpg

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Elastase of U-937 monocytelike cells. Comparisons with elastases derived from human monocytes and neutrophils and murine macrophagelike cells.U-937单核细胞样细胞的弹性蛋白酶。与源自人单核细胞、中性粒细胞及鼠巨噬细胞样细胞的弹性蛋白酶的比较。
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The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases.编码自然杀伤细胞颗粒丝氨酸蛋白酶的基因，即人类组织蛋白酶2（TRYP2）和人类颗粒酶A（HFSP），均定位于5号染色体的q11-q12区域，并确定了细胞毒性淋巴细胞颗粒组织蛋白酶的一个新基因座。
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