Pahl M V, Vaziri N D, Benavides I, Khamiseh G, Oveisi F
Department of Medicine, University of California, Irvine Medical Center 92668.
Proc Soc Exp Biol Med. 1990 Feb;193(2):125-8. doi: 10.3181/00379727-193-43012.
We studied intestinal absorption of vitamin E in rats with experimental renal failure (RF) and in sham-operated normal and pair-fed controls using in vivo perfusion and in vitro everted sacs. The in vivo absorption rates per unit of intestine length were significantly reduced in RF and pair-fed groups. Expression of data per unit of intestine weight gave normal values in the pair-fed but depressed values in the RF animals. Vitamin E uptake in vitro was significantly increased in RF animals, suggesting enhanced permeability. We conclude: (i) vitamin E absorption in vivo is impaired in experimental RF; (ii) this is in part due to reduced nutrient intake; and (iii) disparity between in vivo and in vitro results suggests the presence of some inhibitory influence(s) in intact animals with RF.
我们使用体内灌注和体外外翻肠囊法，研究了实验性肾衰竭（RF）大鼠、假手术正常大鼠以及配对喂养对照组大鼠对维生素E的肠道吸收情况。RF组和配对喂养组每单位肠道长度的体内吸收率显著降低。按每单位肠道重量计算的数据显示，配对喂养组的数值正常，而RF组动物的数值则降低。RF组动物体外维生素E摄取量显著增加，提示通透性增强。我们得出以下结论：（i）实验性RF大鼠体内维生素E吸收受损；（ii）这部分是由于营养摄入减少所致；（iii）体内和体外结果之间的差异表明，RF完整动物体内存在某些抑制性影响因素。
