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限制型减重手术对尿路结石的影响。

The effect of restrictive bariatric surgery on urolithiasis.

机构信息

University of California, San Diego School of Medicine, La Jolla, California, USA.

出版信息

J Endourol. 2013 Feb;27(2):242-4. doi: 10.1089/end.2012.0408. Epub 2012 Nov 7.

Abstract

BACKGROUND AND PURPOSE

Roux-en-Y gastric bypass (RYGB) surgery, a mixed malabsorptive/restrictive procedure, is associated with enteric hyperoxaluria and an increased risk of kidney stones. The incidence of nephrolithiasis after purely restrictive bariatric procedures such as adjustable gastric banding or sleeve gastrectomy has not been well described. We aim to analyze the incidence of kidney stones in patients who undergo either adjustable gastric banding or sleeve gastrectomy.

PATIENTS AND METHODS

In a retrospective study, we analyzed a pool of 332 patients who underwent adjustable gastric banding and 85 patients who underwent sleeve gastrectomy at the University of California, San Diego Center for the Treatment for Obesity within a 54-month period (September 2006 to February 2011). The primary outcomes of urinary calculus diagnosis and surgical treatment were investigated using manual chart review and International Classification of Diseases and Related Health Problems-9 code electronic search.

RESULTS

Within the adjustable gastric banding cohort, we found a person-time incidence rate of 3.40 stone diagnoses per 1000 person-years. Within the sleeve gastrectomy cohort, we found a person-time incidence rate of 5.25 stone diagnoses per 1000 person-years.

CONCLUSIONS

Questions remain whether purely restrictive bariatric procedures such as sleeve gastrectomy or adjustable gastric banding avoid the risk of kidney stones. Our study demonstrates a very low incidence of kidney stones after restrictive bariatric procedures, although larger sample sizes, longer follow-up times, and controlled prospective studies are necessary to validate this finding.

摘要

背景与目的

Roux-en-Y 胃旁路(RYGB)手术是一种混合吸收不良/限制型手术,与肠源性高草酸尿症和肾结石风险增加有关。单纯限制型减重手术(如可调胃带或胃袖切除术)后肾结石的发生率尚未得到很好的描述。我们旨在分析行可调胃带或胃袖切除术的患者肾结石的发生率。

患者与方法

在一项回顾性研究中,我们分析了在加利福尼亚大学圣地亚哥肥胖治疗中心接受可调胃带治疗的 332 例患者和接受胃袖切除术的 85 例患者的数据,研究时间为 54 个月(2006 年 9 月至 2011 年 2 月)。通过手动图表审查和国际疾病分类和相关健康问题-9 代码电子搜索,调查尿结石诊断和手术治疗的主要结果。

结果

在可调胃带组中,我们发现每 1000 人年有 3.40 例结石诊断的人数发病率。在胃袖切除术组中,我们发现每 1000 人年有 5.25 例结石诊断的人数发病率。

结论

关于单纯限制型减重手术(如胃袖切除术或可调胃带)是否可以避免肾结石风险的问题仍存在疑问。我们的研究表明,限制型减重手术后肾结石的发生率非常低,尽管需要更大的样本量、更长的随访时间和对照前瞻性研究来验证这一发现。

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