Lu C H, Li Y Y, Li L J, Liang L Y, Shen Y M
School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China.
Drug Discov Ther. 2012 Aug;6(4):194-7.
Geranium nepalense Sweet is a common Chinese herbal medicine and has been used as influenza, dysentery, antiphlogistic and analgesic tonic, hemostatic, stomachic, and antidiabetic drugs. The anti-inflammatory effects of G. nepalense on tetradecanoyl phorbol acetate (TPA)-induced mouse ear edema were studied in this work. The results showed that ethyl acetate fraction of the water extract of G. nepalense possessed significant activity at 2.5 g/kg (p < 0.01) with aspirin as a positive control (0.6 g/kg). Six polyphenolic compounds, including three flavonoids, i.e. kaempferol, kaempferol-7-O-β-D-glucopyranoside, and quercetin-7-O-α-rhamnopyranoside, and two tannins, i.e. pyrogallol and gallic acid, and one lignin, i.e. epipinoresinol, were isolated and characterized from ethyl acetate fraction. The isolation of polyphenols provides a clue for beneficial effects of G. nepalense in the demonstrated anti-inflammatory activity.
尼泊尔老鹳草是一种常见的中草药，已被用作治疗流感、痢疾、消炎止痛滋补剂、止血药、健胃药和抗糖尿病药物。本研究探讨了尼泊尔老鹳草对十四酰佛波醇乙酸酯（TPA）诱导的小鼠耳肿胀的抗炎作用。结果表明，以阿司匹林（0.6 g/kg）为阳性对照，尼泊尔老鹳草水提取物的乙酸乙酯部位在2.5 g/kg时具有显著活性（p < 0.01）。从乙酸乙酯部位分离并鉴定出6种多酚化合物，包括3种黄酮类化合物，即山奈酚、山奈酚-7-O-β-D-吡喃葡萄糖苷和槲皮素-7-O-α-L-鼠李糖苷，2种单宁，即连苯三酚和没食子酸，以及1种木质素，即表松脂醇。多酚的分离为尼泊尔老鹳草在已证明的抗炎活性中的有益作用提供了线索。
