Velázquez-González Claudia, Cariño-Cortés Raquel, Gayosso de Lucio Juan A, Ortiz Mario I, De la O Arciniega Minarda, Altamirano-Báez Diana A, Ángeles Luis Jiménez-, Bautista-Ávila Mirandeli
Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda la Concepción, Tilcuautla, Hidalgo, México.
BMC Complement Altern Med. 2014 Dec 17;14:506. doi: 10.1186/1472-6882-14-506.
Geranium bellum Rose, locally known as "Pata de león", is a perennial plant distributed in the mountains of Hidalgo, Mexico. It is widely used in Mexican traditional medicine to treat fever, pain, and gastrointestinal disorders. To date, there are not published studies regarding the in vivo antinociceptive and anti-inflammatory potential of the acetone-aqueous extract from the aerial parts of G. bellum.
Antinociceptive effects of the acetone-aqueous G. bellum (AGB) extract and the isolated compounds were assessed using experimental pain models, including thermal nociception like hot plate test, and chemical nociception induced by intraperitoneal acetic acid or subplantar formalin injection in vivo. The anti-inflammatory properties of the extract were studied using systemic administration in carrageenan-induced paw edema.
Intra-gastric administration of AGB (75, 150, and 300 mg/kg) showed a dose-dependent antinociceptive effect in intraperitoneal acetic acid (writhing), thermal nociception in CD1 mice, and subplantar formalin models, as well as anti-inflammatory effect in carrageenan- induced paw edema in Wistar rats. Geraniin and quercetin showed the highest antinociceptive activity in writhing test, whereas ellagic acid was the most active compound in the hot plate model.
These studies provide evidences that G. bellum shows antinociceptive and anti- inflammatory effects, and gives support to its use in treating pain in Mexican traditional medicine.
香叶天竺葵，当地称为“狮爪”，是一种多年生植物，分布于墨西哥伊达尔戈州的山区。它在墨西哥传统医学中被广泛用于治疗发烧、疼痛和胃肠道疾病。迄今为止，尚未有关于香叶天竺葵地上部分丙酮-水提取物的体内抗伤害感受和抗炎潜力的研究发表。
使用实验性疼痛模型评估香叶天竺葵丙酮-水提取物（AGB）和分离出的化合物的抗伤害感受作用，包括热伤害感受如热板试验，以及体内腹腔注射乙酸或足底注射福尔马林诱导的化学伤害感受。通过在角叉菜胶诱导的爪肿胀中进行全身给药来研究提取物的抗炎特性。
胃内给予AGB（75、150和300 mg/kg）在腹腔注射乙酸（扭体）、CD1小鼠的热伤害感受和足底福尔马林模型中显示出剂量依赖性的抗伤害感受作用，以及在Wistar大鼠角叉菜胶诱导的爪肿胀中显示出抗炎作用。老鹳草素和槲皮素在扭体试验中显示出最高的抗伤害感受活性，而鞣花酸是热板模型中最具活性的化合物。
这些研究提供了证据，表明香叶天竺葵具有抗伤害感受和抗炎作用，并支持其在墨西哥传统医学中用于治疗疼痛。
