Sidney H, Mage G, Bruhat M A
Polyclinique gynécologique obstétrique, médicine de la reproduction, Université Clermont-Ferrand I, France.
Rev Prat. 1990 Jan 1;40(1):12-8.
Pre-invasive lesions of the uterine cervix are histological abnormalities corresponding to dysplasias and also called cervical intraepithelial neoplasias (CIN). These lesions are more or less severe, but they do not cross the basal membrane. The histological diagnosis rests on disorders of maturation and differentiation and on the presence of nuclear abnormalities and abnormal mitotic activity. No cytological, histological or colposcopic criteria are available to assess the evolutive potential of these lesions. A CIN III lesion has a 60-70 p. 100 risk of becoming a cancer. One-third of pure condylomas are thought to be due to an oncogenic virus. The diagnosis of CIN rests on colposcopy, cytology and histology. Depending on the severity of the lesion, treatment consists of local destruction by cryotherapy, electrocoagulation or laser vaporization; conization may also be used. Laser vaporization is not contra-indicated in CIN III. Treating cervical dysplasias is the best way of preventing cancer.
子宫颈的癌前病变是与发育异常相对应的组织学异常,也称为宫颈上皮内瘤变(CIN)。这些病变程度不一,但不会穿过基底膜。组织学诊断基于成熟和分化紊乱以及核异常和异常有丝分裂活动的存在。没有细胞学、组织学或阴道镜检查标准可用于评估这些病变的发展潜力。CIN III病变有60 - 70%的风险会发展为癌症。三分之一的单纯性湿疣被认为是由致癌病毒引起的。CIN的诊断基于阴道镜检查、细胞学检查和组织学检查。根据病变的严重程度,治疗方法包括冷冻疗法、电凝术或激光汽化术进行局部破坏;也可采用锥形切除术。激光汽化术对CIN III并非禁忌。治疗宫颈发育异常是预防癌症的最佳方法。