Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
AIDS Behav. 2013 Jan;17(1):168-73. doi: 10.1007/s10461-012-0319-6.
Many HIV-infected injection drug users (IDUs) continue to use illicit substances despite being in substance use treatment. Substance use is associated with non-adherence to HIV medications; however underlying mechanisms regarding this relation are understudied. The current investigation examined the role of substance use coping in terms of the relation between substance use and HIV medication adherence. Participants were 121 HIV-infected IDUs (41 % female, M age = 47, SD = 7.1) in opioid dependence treatment. Participants completed self-report questionnaires, were administered clinical interviews and oral toxicology screens, and used a medication-event-monitoring-system cap to assess 2 week HIV medication adherence. The use of cocaine and multiple substances were significantly related to decreased medication adherence. Substance use coping mediated these associations. Findings highlight the importance of assessing, monitoring, and targeting ongoing substance use, and ways to increase positive coping for HIV-infected IDUs in substance use treatment to aid in HIV medication adherence.
许多感染艾滋病毒的注射吸毒者（IDU）尽管正在接受药物滥用治疗，但仍继续使用非法药物。药物使用与不遵守艾滋病毒药物治疗方案有关；然而，关于这种关系的潜在机制还研究得不够。目前的研究调查了物质使用应对在物质使用与艾滋病毒药物治疗依从性之间关系中的作用。参与者为 121 名感染艾滋病毒的 IDU（41%为女性，M 年龄=47，SD=7.1），他们正在接受阿片类药物依赖治疗。参与者完成了自我报告问卷，接受了临床访谈和口服毒理学筛查，并使用药物事件监测系统帽来评估 2 周的 HIV 药物治疗依从性。可卡因和多种物质的使用与降低药物治疗依从性显著相关。物质使用应对中介了这些关联。研究结果强调了评估、监测和针对正在进行的物质使用的重要性，以及增加感染艾滋病毒的 IDU 在药物滥用治疗中积极应对的方法，以帮助提高 HIV 药物治疗依从性。
