Rosa Marilin, Mohammadi Amir
Department of Pathology and Laboratory Medicine, University of Florida, College of Medicine, Jacksonville, Florida.
Diagn Cytopathol. 2014 May;42(5):431-5. doi: 10.1002/dc.22931. Epub 2012 Sep 25.
Fibrolamellar carcinoma (FC) is an uncommon tumor that usually arises in non-cirrhotic livers of adolescents or young adults. It differs clinically from hepatocellular carcinoma in its better prognosis and lack of gender predilection. Cytologically, the tumor is composed of large polygonal cells with abundant cytoplasm, pleomorphic nuclei, and prominent large nucleoli. A variant of FC with mucinous differentiation has been previously described. These tumors have been regarded as combined hepatocellular cholangiocarcinomas. Herein, we report the case of a 44-year-old Asian female with a large liver mass present for approximately two years. Core needle biopsy with imprint cytology demonstrated FC with areas of intracellular mucin. To our knowledge, cytological features of this rare tumor have not been described before.
纤维板层癌（FC）是一种罕见的肿瘤，通常发生于青少年或年轻成年人的非肝硬化肝脏。它在临床上与肝细胞癌不同，预后较好且无性别偏好。在细胞学上，该肿瘤由具有丰富细胞质、多形性核和突出大核仁的大的多边形细胞组成。先前已描述过具有黏液分化的FC变体。这些肿瘤被视为肝细胞胆管癌的组合。在此，我们报告一例44岁亚洲女性，有一个大的肝脏肿块，已存在约两年。粗针穿刺活检及印片细胞学检查显示为具有细胞内黏液区域的FC。据我们所知，这种罕见肿瘤的细胞学特征此前尚未被描述过。
