糖尿病性偏侧舞蹈症-偏侧投掷症患者纹状体代谢的变化
Change in striatal metabolism in diabetic haemichorea-haemiballism.
作者信息
Hashimoto Takao, Oguchi Kazuhiro, Takeuchi Ryo
机构信息
Center for Neurological Diseases, Aizawa Hospital, Matsumoto, Japan.
出版信息
BMJ Case Rep. 2012 Sep 24;2012:bcr2012006405. doi: 10.1136/bcr-2012-006405.
We studied metabolic changes in relation to chorea in two patients with diabetic haemichorea-haemiballism using positron emission tomography with (18)F-fluorodeoxyglucose. Metabolism of the striatum and globus pallidus did not change in the acute choreic stage, but it decreased in the later stage after the amelioration of chorea. Striatal and pallildal hypometabolism in the late stage in diabetic haemichorea-haemiballism may reflect tissue ischaemia with gliosis. Previous studies have demonstrated striatal hypometabolism in neurodegenerative choreic disorders and striatal hypermetabolism in acute inflammatory choreic disorders. Previous findings as well as our results suggest that striatal and pallidal metabolic changes may be correlated with histological changes more than with functional changes relevant to chorea.
我们使用正电子发射断层扫描术和（18）F-氟脱氧葡萄糖研究了两名糖尿病性偏侧舞蹈症-偏侧投掷症患者与舞蹈症相关的代谢变化。在急性舞蹈症阶段，纹状体和苍白球的代谢没有变化，但在舞蹈症改善后的后期阶段代谢降低。糖尿病性偏侧舞蹈症-偏侧投掷症后期的纹状体和苍白球代谢减退可能反映了伴有胶质增生的组织缺血。先前的研究已证实在神经退行性舞蹈症中纹状体代谢减退，在急性炎症性舞蹈症中纹状体代谢亢进。先前的发现以及我们的结果表明，纹状体和苍白球的代谢变化可能与组织学变化的相关性大于与舞蹈症相关的功能变化的相关性。
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