Denver Health and Hospitals, Rocky Mountain Poison and Drug Center, 777 Bannock St #0180, Denver, CO 80204, USA.
Pediatrics. 2012 Oct;130(4):e1026-9. doi: 10.1542/peds.2011-3849. Epub 2012 Sep 24.
Human glycol ether poisonings are sparsely reported in the medical literature. We describe a healthy 22-month-old boy who accidentally drank up to 330 mL of brake fluid containing a 75% bleed of various glycol ethers (5%-50% polyethylene glycol monomethyl ether, 15%-40% triethylene glycol monoethyl ether, 1%-30% triethylene glycol monomethyl ether, 1%-25% triethylene glycol monobutyl ether, 1%-20% polyethylene glycol, monobutyl ether, 1%-20% triethylene glycol, and <10% of other glycol ethers). Within 4 hours, he became somnolent and developed a persistent metabolic acidosis. Thirty minutes later, he received 1 dose of fomepizole. Neither progression nor improvement in clinical or metabolic status was noted after the fomepizole. He received hemodialysis for 3 hours ∼8 hours after ingestion, and his symptoms resolved resulting in an uneventfully recovery.
在医学文献中，人类乙二醇醚中毒的报道很少。我们描述了一名健康的 22 个月大的男孩，他不慎喝下了多达 330 毫升的刹车油，其中含有 75%的各种乙二醇醚（5%-50%的聚乙二醇单甲醚、15%-40%的三乙二醇单乙醚、1%-30%的三乙二醇单甲醚、1%-25%的三乙二醇单丁醚、1%-20%的聚乙二醇单丁醚、1%-20%的三乙二醇和 <10%的其他乙二醇醚）。在 4 小时内，他变得昏昏欲睡，并出现持续的代谢性酸中毒。30 分钟后，他接受了 1 剂 fomepizole 治疗。在接受 fomepizole 治疗后，他的临床和代谢状况既没有恶化也没有改善。他在摄入后 3 小时到 8 小时接受了血液透析治疗，症状缓解，最终康复，无并发症。
