氟-18-氟脱氧葡萄糖正电子发射断层扫描在评估骨肉瘤患者新辅助治疗反应中的作用
The Role of Fluorine-18-fluorodeoxyglucose Positron Emission Tomography in Assessing the Response to Neoadjuvant Treatment in Patients with Osteosarcoma.
作者信息
Caldarella Carmelo, Salsano Marco, Isgrò Maria Antonietta, Treglia Giorgio
机构信息
Department of Bioimaging and Radiological Sciences, Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy.
出版信息
Int J Mol Imaging. 2012;2012:870301. doi: 10.1155/2012/870301. Epub 2012 Sep 13.
Aim. The objective of this study is to systematically review the role of positron emission tomography (PET) and PET/computed tomography (PET/CT) with fluorine-18-fluorodeoxyglucose (FDG) in assessing the response to neoadjuvant treatment in patients with osteosarcoma (OS). Methods. A comprehensive literature search of published studies through March 2012 in PubMed/MEDLINE, Embase, and Scopus databases regarding whole-body FDG-PET and FDG-PET/CT in patients with OS was performed. Results. Twenty-two studies have investigated the role of FDG-PET and FDG-PET/CT in the evaluation of response to neoadjuvant treatment with either chemotherapy or radiation therapy in patients with OS. The main findings of these studies are presented. Conclusion. FDG-PET or PET/CT seems to be sensitive and reliable diagnostic tools in the assessment of metabolic response to treatment in patients with OS, after baseline PET evaluation has been performed in advance. However, false positive findings due to inflammation in sites of tumoral response should be considered.
目的。本研究的目的是系统评价正电子发射断层扫描（PET）及氟-18-氟脱氧葡萄糖（FDG）PET/计算机断层扫描（PET/CT）在评估骨肉瘤（OS）患者新辅助治疗反应中的作用。方法。通过对PubMed/MEDLINE、Embase和Scopus数据库进行全面文献检索，查找截至2012年3月发表的关于全身FDG-PET及FDG-PET/CT在OS患者中的研究。结果。22项研究探讨了FDG-PET及FDG-PET/CT在评估OS患者对化疗或放疗新辅助治疗反应中的作用。呈现了这些研究的主要发现。结论。在预先进行基线PET评估后，FDG-PET或PET/CT似乎是评估OS患者治疗代谢反应的敏感且可靠的诊断工具。然而，应考虑肿瘤反应部位炎症导致的假阳性结果。
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