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儿科肿瘤学中影像生物标志物现状白皮书。

White paper on the current state of imaging biomarkers in paediatric oncology.

作者信息

Nievelstein Rutger A J, Borgwardt Lise, Inarejos Clemente Emilio J, Von Kalle Thekla, Kyncl Martin, Lequin Maarten H, Littooij Annemieke S, Pace Erika, Di Paolo Pier L, Van Rijn Rick R, Rogasch Julian M M, Schäfer Jurgen, Sefic Pasic Irmina, Spezzacatene Anita, Tolboom Nelleke, Wan Simon M, Zucchetta Pietro

机构信息

Department of Radiology and Nuclear Medicine, Division Imaging and Oncology, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85500, 3508, GA, Utrecht, Netherlands.

Department of Radiology and Nuclear Medicine, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.

出版信息

Pediatr Radiol. 2025 Sep 2. doi: 10.1007/s00247-025-06372-6.

DOI:10.1007/s00247-025-06372-6
PMID:40892085
Abstract

In paediatric oncology, imaging biomarkers play an increasing role in diagnostic imaging and research. They can be used for prediction, detection, staging, and grading of diseases, as well as for assessment of response to treatment. Imaging biomarkers are complementary to tissue-based biomarkers, enabling a more personalised approach in oncology care. In this white paper by the European Society of Paediatric Radiology (ESPR) Oncology Taskforce and European Association of Nuclear Medicine (EANM) Paediatrics Committee, an overview is given of the current knowledge on the use of imaging biomarkers in general and per tumour group.

摘要

在儿科肿瘤学中,影像生物标志物在诊断成像和研究中发挥着越来越重要的作用。它们可用于疾病的预测、检测、分期和分级,以及评估治疗反应。影像生物标志物是基于组织的生物标志物的补充,能够在肿瘤护理中采用更个性化的方法。在欧洲儿科放射学会(ESPR)肿瘤学特别工作组和欧洲核医学协会(EANM)儿科学委员会撰写的本白皮书中,概述了关于影像生物标志物的一般用途以及各肿瘤组的当前知识。

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本文引用的文献

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Total-Body PET/CT: Pros and Cons.全身PET/CT:利弊
Semin Nucl Med. 2025 Jan;55(1):11-20. doi: 10.1053/j.semnuclmed.2024.07.003. Epub 2024 Sep 17.
3
Performing [F]MFBG Long-Axial-Field-of-View PET/CT Without Sedation or General Anesthesia for Imaging of Children with Neuroblastoma.在无镇静或全身麻醉的情况下进行[F]MFBG长轴视野PET/CT对神经母细胞瘤患儿进行成像
J Nucl Med. 2024 Aug 1;65(8):1286-1292. doi: 10.2967/jnumed.123.267256.
4
The evidence-based role of catecholaminergic PET tracers in Neuroblastoma. A systematic review and a head-to-head comparison with mIBG scintigraphy.儿茶酚胺能PET示踪剂在神经母细胞瘤中的循证作用。一项系统综述及与间碘苄胍闪烁显像的直接比较。
Eur J Nucl Med Mol Imaging. 2024 Feb;51(3):756-767. doi: 10.1007/s00259-023-06486-9. Epub 2023 Nov 14.
5
Review of imaging recommendations from Response Assessment in Pediatric Neuro-Oncology (RAPNO).儿科神经肿瘤学反应评估(RAPNO)的影像学推荐综述。
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J Clin Oncol. 2023 Nov 20;41(33):5187-5199. doi: 10.1200/JCO.23.01059. Epub 2023 Sep 29.
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