Institute of Nuclear Medicine, Positron Emission Tomography Centre, Catholic University of the Sacred Heart, Largo Gemelli 8, Rome, 00168, Italy.
Clin Rheumatol. 2011 Oct;30(10):1265-75. doi: 10.1007/s10067-011-1828-9. Epub 2011 Aug 11.
The objective of this study is to systematically review the role of positron emission tomography (PET) and PET/computed tomography (PET/CT) with fluorine-18-fluorodeoxyglucose (FDG) in patients with large-vessel vasculitis (LVV). A comprehensive literature search of published studies through April 2011 in PubMed/MEDLINE and Scopus databases regarding whole-body FDG-PET and PET/CT in patients with LVV was performed. We identified 32 studies including 604 LVV patients. The main findings of these studies are presented. The conclusions are the following: (1) FDG-PET and PET/CT are useful imaging methods in the initial diagnosis and in the assessment of activity and extent of disease in patients with LVV; (2) the correlation between FDG-PET findings and serological levels of inflammatory markers, as well as the usefulness of FDG-PET and PET/CT in evaluating treatment response, remains unclear; (3) it appears that there is a superiority of FDG-PET and PET/CT over conventional imaging methods in the diagnosis of LVV, but not in assessing disease activity under immunosuppressive treatment, in predicting relapse or in evaluating vascular complications; and (4) given the heterogeneity between studies with regard to PET analysis and diagnostic criteria, a standardization of the technique is needed.
本研究旨在系统回顾正电子发射断层扫描（PET）和氟-18-氟代脱氧葡萄糖（FDG）联合 PET/计算机断层扫描（PET/CT）在大动脉血管炎（LVV）患者中的作用。通过 PubMed/MEDLINE 和 Scopus 数据库对截至 2011 年 4 月发表的有关全身 FDG-PET 和 LVV 患者 PET/CT 的文献进行了全面检索。我们共识别出 32 项研究，共纳入 604 例 LVV 患者。现将这些研究的主要发现总结如下。结论如下：（1）FDG-PET 和 PET/CT 是 LVV 患者初始诊断以及评估疾病活动度和范围的有用影像学方法；（2）FDG-PET 结果与炎症标志物的血清学水平之间的相关性，以及 FDG-PET 和 PET/CT 在评估治疗反应方面的作用尚不清楚；（3）FDG-PET 和 PET/CT 在诊断 LVV 方面似乎优于传统影像学方法，但在评估免疫抑制治疗下的疾病活动度、预测复发或评估血管并发症方面则并非如此；（4）鉴于研究之间在 PET 分析和诊断标准方面存在异质性，需要对该技术进行标准化。
