Treglia Giorgio, Taralli Silvia, Calcagni Maria Lucia, Maggi Fabio, Giordano Alessandro, Bonomo Lorenzo
Nuclear Medicine Unit, Department of Bioimaging and Radiological Sciences, Catholic University of Sacred Heart, Rome, Italy.
J Comput Assist Tomogr. 2011 May-Jun;35(3):387-93. doi: 10.1097/RCT.0b013e318219f810.
This study was designed to review the emerging role of fluorine 18 fluorodeoxyglucose (¹⁸F-FDG)-positron emission tomography (PET) CT/computed tomography (PET/CT) in patients with mycobacteriosis.
A comprehensive literature search of published studies through October 2010 in PubMed/MEDLINE database regarding ¹⁸F-FDG-PET and PET/CT in patients with mycobacteriosis was performed.
Ultimately, we identified 16 studies comprising a total of 220 patients with mycobacteriosis. Main findings of the included studies are presented.
(1) Mycobacteriosis commonly causes increased ¹⁸F-FDG uptake; therefore, positive ¹⁸F-FDG-PET results should be interpreted with caution in differentiating benign from malignant abnormalities. (2) ¹⁸F-FDG-PET and PET/CT are potentially useful in detecting sites of Mycobacterium infection. (3) Dual-phase ¹⁸F-FDG-PET is not useful for the differential diagnosis between malignant lesions and sites of Mycobacterium infection. (4) ¹⁸F-FDG-PET and PET/CT are useful for the evaluation of disease activity and in monitoring response to therapy in patients with mycobacteriosis. (5) Dual-tracer PET and PET/CT are potentially useful for presumptive diagnosis of solitary pulmonary nodules.
本研究旨在回顾氟代脱氧葡萄糖（¹⁸F-FDG）正电子发射断层扫描（PET）CT/计算机断层扫描（PET/CT）在分枝杆菌病患者中的新作用。
通过对PubMed/MEDLINE数据库中截至2010年10月发表的关于¹⁸F-FDG-PET和PET/CT在分枝杆菌病患者中的研究进行全面文献检索。
最终，我们确定了16项研究，共纳入220例分枝杆菌病患者。呈现了纳入研究的主要发现。
（1）分枝杆菌病通常导致¹⁸F-FDG摄取增加；因此，在鉴别良性与恶性异常时，对¹⁸F-FDG-PET阳性结果的解读应谨慎。（2）¹⁸F-FDG-PET和PET/CT在检测分枝杆菌感染部位方面可能有用。（3）双期¹⁸F-FDG-PET对恶性病变与分枝杆菌感染部位的鉴别诊断无用。（4）¹⁸F-FDG-PET和PET/CT对评估分枝杆菌病患者的疾病活动度及监测治疗反应有用。（5）双示踪剂PET和PET/CT对孤立性肺结节的初步诊断可能有用。
