University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Centers, Pittsburgh, PA 15213, USA.
Retrovirology. 2012 Sep 25;9:78. doi: 10.1186/1742-4690-9-78.
Activation of the NF-κB transcription factors by the viral protein Tax plays a vital role in the pathogenesis of diseases associated with human T-cell lymphotropic virus type I (HTLV-I). The Tax oncoprotein undergoes constitutive K63-linked ubiquitination and sumoylation; however, the roles and molecular mechanisms of these post-translational modifications in Tax-mediated NF-κB activation are being debated. Here, we discuss our current understanding of Tax activation of NF-κB, with a focus on the controversies and the challenges that we are facing.
病毒蛋白 Tax 对 NF-κB 转录因子的激活在与人类 T 细胞白血病病毒 I 型（HTLV-I）相关疾病的发病机制中起着至关重要的作用。Tax 癌蛋白发生组成性 K63 连接的泛素化和 SUMO 化；然而，这些翻译后修饰在 Tax 介导的 NF-κB 激活中的作用和分子机制仍存在争议。在这里，我们讨论我们对 Tax 激活 NF-κB 的现有理解，重点讨论争议和我们面临的挑战。
