Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scorpus, Israel.
Clin Exp Rheumatol. 2012 May-Jun;30(3 Suppl 72):S90-5. Epub 2012 Sep 25.
The last two years have been marked by many studies trying to better characterize the clinical features of FMF in children and proposal of new treatment for those who are resistant to colchicine. In addition, many studies tried to address the potential effect of genetic modifiers on FMF and the potential effect of MEFV mutations on other inflammatory diseases. The main points arose from these studies include a breakthrough in the therapeutic approach for FMF and the lack of consistency regarding the reciprocal effect of MEFV mutations on other diseases and the effect of genetic modifiers on FMF. The highlights of these studies, their potential clinical implications and the unmet needs, which are still to be addressed, are summarised in this review.
过去两年的研究旨在更好地描述儿童纤维肌痛综合征的临床特征，并为那些对秋水仙碱耐药的患者提供新的治疗方法。此外，许多研究试图探讨遗传修饰物对纤维肌痛综合征的潜在影响，以及 MEFV 突变对其他炎症性疾病的潜在影响。这些研究的主要观点包括纤维肌痛综合征治疗方法的突破，以及 MEFV 突变对其他疾病的相互影响以及遗传修饰物对纤维肌痛综合征的影响方面缺乏一致性。本文综述了这些研究的要点、它们的潜在临床意义以及仍待解决的未满足需求。
